- Title
- Effects of birth cohorts on the irritable bowel syndrome support early-life risk factors
- Creator
- Brummond, Neil R.; Locke III, G. Richard; Choung, Rok Seon; Chang, Joseph Y.; Schleck, Cathy D.; Zinsmeister, Alan R.; Talley, Nicholas J.
- Relation
- Digestive Diseases and Sciences Vol. 60, Issue 7, p. 2112-2118
- Publisher Link
- http://dx.doi.org/10.1007/s10620-015-3565-4
- Publisher
- Springer
- Resource Type
- journal article
- Date
- 2015
- Description
- Background: Irritable bowel syndrome (IBS) is common with prevalence reported between 10 and 20 %. IBS clusters in families but it is unknown whether this is explained by a common environment, genes, or both. If early-life factors are important, IBS might be expected to demonstrate a birth cohort phenomenon. Aim: To investigate whether there is a birth cohort phenomenon for subjects with IBS. Methods: Validated questionnaires were sent to a random sample of Olmsted County, Minnesota, residents who recorded gastrointestinal symptoms; IBS diagnosis was based on the modified Rome criteria. Birth cohorts were chosen a priori based on historical national trends in birth weights using 10-year increments. Logistic regression was used to develop odds ratios to assess the association of IBS with calendar period, birth cohort, age, gender, and somatic symptom score. Results: A total of 4,893 surveys were completed with an overall survey response rate of 58 %. The survey responders were between 25 and 94 years of age and 53 % were female. The overall prevalence of IBS was 16.2 % (95 % CI 15.3–17.4). The univariate association of IBS with birth cohort was significant (p < 0.001) as was the association adjusted for age and gender. The prevalence of IBS was highest for the birth cohort 1963–1972 with an odds ratio of 2.6 (95 % CI 0.97–7.0, p = 0.058). Conclusions: Population-based data support a possible birth cohort phenomenon in IBS. If correct, early-life risk factors likely play a key role in the development of IBS.
- Subject
- irritable bowel syndrome; birth cohort; functional gastrointestinal disorders; low birth weight
- Identifier
- http://hdl.handle.net/1959.13/1314342
- Identifier
- uon:22752
- Identifier
- ISSN:1573-2568
- Language
- eng
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